Chapter 3 Pain

  1. Misch LJ, Duffield TF, Millman ST, et al. 2007. An investigation into the practices of dairy producers and veterinarians in dehorning dairy calves in Ontario. Can Vet J 48:1249. PUBMED Abstract
  2. Huxley JN, Whay HR. 2006. Current attitudes of cattle practitioners to pain and the use of analgesics in cattle. Vet Record 159:662. PUBMED Abstract
  3. Hewson CJ, Dohoo IR, Lemke KA, et al. 2007. Canadian veterinarians' use of analgesics in cattle, pigs, and horses in 2004 and 2005. Can Vet J 48:155. PUBMED Abstract
  4. Laven RA, Huxley JN, Whay HR, et al. 2009. Results of a survey of attitudes of dairy veterinarians in New Zealand regarding painful procedures and conditions in cattle. New Zeal Vet J 57:215. PUBMED Abstract
  5. Fajt VR, Wagner SA, Norby B, et al. 2011. Analgesic drug administration and attitudes about analgesia in cattle among bovine practitioners in the United States. J Am Vet Med Assoc 238:755. PUBMED Abstract
  6. Thomsen PT, Gidekull M, Kerskin MS, et al. 2010. Scandinavian bovine practitioners' attitudes to the use of analgesics in cattle. Vet Record 167:2256. PUBMED Abstract
  7. Zimmermann M. 1986. Behavioural investigations of pain in animals, pp 16-29. In Duncan IJH, Molony V (eds), Assessing pain in farm animals. Office for Official Publications of the European Communities, Brussels.
  8. Langford DJ, Bailey AL, Chanda ML, et al. 2010. Coding of facial expressions of pain in the laboratory mouse. Nat Methods 7:447. PUBMED Abstract
  9. Flowers FC, Weary DM. 2006. Effects of hoof pathologies on subjective assessments of dairy cow gait. J Dairy Sci 89:139. PUBMED Abstract
  10. Rushen J, Pombourcq E, de Passille AM. 2007. Validation of two measures of lameness in dairy cows. Appl Anim Behav Sci 106:173.
  11. Martin P, Bateson P. 2007. Measuring behaviour: an introductory guide, ed 3, p 187. Cambridge University Press, Wallingford, England.
  12. Higginson JH, Millman ST, Leslie KE, et al. 2010. Validation of the new pedometry system for use in behaviour research and lameness detection in dairy cattle, pp 132-133. In Proceedings of the First North American Conference on Precision Dairy Management. Toronto.
  13. Schwartzkopf-Genswein KS, Stookey JM, Crowe TG, et al. 1998. Comparison of image analysis, exertion force, and behavior measurements for use in the assessment of beef cattle responses to hot-iron and freeze branding. J Anim Sci 76:972. PUBMED Abstract
  14. Weary DM, Braithwaite LA, Fraser D. 1998. Vocal response to pain in piglets. Appl Anim Behav Sci 56:161.
  15. Watts JM, Stookey JM. 1999. Effects of restraint and branding on rates and acoustic parameters of vocalization in beef cattle. Appl Anim Behav Sci 62:125.
  16. Watts JM, Stookey JM. 2001. The propensity of cattle to vocalize during handling and isolation is affected by phenotype. Appl Anim Behav Sci 74:81.
  17. Heinrich A, Duffield TF, Lissemore KD, et al. 2010. The effect of meloxicam on behavior and pain sensitivity of dairy calves following cautery dehorning with a local anesthetic. J Dairy Sci 93:2450. PUBMED Abstract
  18. Tapper TR. 2011. An investigation of pressure algometry and thermal sensitivity for assessing pain associated with a sow lameness model and calf disbudding. Master's of science thesis. Department of Biomedical Science, Iowa State University, Ames, IA.
  19. Veissier I, Rushen J, Colwell D, et al. 2000. A laser-based method for measuring thermal nociception of cattle. Appl Anim Behav Sci 66:289. PUBMED Abstract
  20. Herskin MS, Muller R, Schrader L, et al. 2003. A laser-based method to measure thermal nociception in dairy cows: short-term repeatability and effects of power output and skin condition. J Anim Sci 81:945. PUBMED Abstract
  21. Rushen J. 1986. Aversion of sheep to electro-immobilization and physical restraint. Appl Anim Behav Sci 15:315. PUBMED Abstract
  22. Coetzee JF, Nutsch A, Barbur LA, et al. 2010. A survey of castration methods and associated livestock management practices performed by bovine veterinarians in the United States. BMC Vet Res 6:12. PUBMED Abstract
  23. Ley SJ, Waterman AE, Livingston A. 1996. Measurement of mechanical thresholds. Plasma cortisol and catecholamines in control and lame cattle: a preliminary study. Res Vet Sci 61:172. PUBMED Abstract
  24. Whay HR, Waterman AE, Webster AJ, et al. 1998. The influence of lesion type on the duration of hyperplasia associated with hindlimb lameness in dairy cattle. Vet J 156:23. PUBMED Abstract
  25. Whay HR, Webster AJ, Waterman-Pearson AE. 2005. Role of ketoprofen in the modulation of hyperplasia associated with lameness in dairy cattle. Vet Rec 157:729. PUBMED Abstract
  26. Flower FC, Sedlbauer M, Carter E, et al. 2008. Analgesics improve the gait of lame dairy cattle. J Dairy Sci 91:3010. PUBMED Abstract
  27. Smith GW, Davis JL, Tell LA, et al. 2008. Extralabel use of nonsteroidal anti-inflammatory drugs in cattle. J Am Vet Med Assoc 232:697. PUBMED Abstract
  28. Muir WW, Hubbell JAE, Skarda R, Bednarski RM. 1995. Local anesthesia in cattle, sheep, goats, and pigs, pp 53-77. In Muir WM, Hubbell JAE, Skarda R, Bednarski RM (eds), Handbook of veterinary anesthesia, ed 2. Mosby, St Louis, MO.
  29. Dehghani SN, Bigham AS. 2009. Comparison of caudal epidural anesthesia by use of lidocaine versus a lidocaine-magnesium sulfate combination in cattle. Am J Vet Res 70:194. PUBMED Abstract
  30. Kara H, Sahin N, Ulusan V, et al. 2002. Magnesium infusion reduces perioperative pain. Eur J Anaesthesiol 19:52. PUBMED Abstract
  31. USP Veterinary Pharmaceutical Information Monographs—Anti-inflammatories. 2004. Flunixin. J Vet Pharmacol Ther 27:70. PUBMED Abstract
  32. USP Veterinary Pharmaceutical Information Monographs—Anti-inflammatories. 2004. Phenylbutazone. J Vet Pharmacol Ther 27:92. PUBMED Abstract
  33. Lees P, Ayliffe T, Maitho TE, et al. 1988. Pharmacokinetics, metabolism and excretion of phenylbutazone in cattle following intravenous, intramuscular and oral administration. Res Vet Sci 44:57. PUBMED Abstract
  34. Landoni MF, Cunningham FM, Lees P. 1995. Pharmacokinetics and pharmacodynamics of ketoprofen in calves applying PK/PD modeling. J Vet Pharmacol Ther 18:315. PUBMED Abstract
  35. USP Veterinary Pharmaceutical Information Monographs—Anti-inflammatories. 2004. Ketoprofen. J Vet Pharmacol Ther 27:75. PUBMED Abstract
  36. USP Veterinary Pharmaceutical Information Monographs—Anti-inflammatories. 2004. Aspirin. J Vet Pharmacol Ther 27:4. PUBMED Abstract
  37. Kotschwar JL, Coetzee JF, Anderson DE, et al. 2009. Analgesic efficacy of sodium salicylate in an amphotericin B induced bovine synovitis-arthritis model. J Dairy Sci J 92:3731. PUBMED Abstract
  38. Gingerich DA, Baggot JD, Yeary RA. 1975. Pharmacokinetics and dosage of aspirin in cattle. J Am Vet Med Assoc 167:945. PUBMED Abstract
  39. USP Veterinary Pharmaceutical Information Monographs—Anti-inflammatories. 2004. Carprofen. J Vet Pharmacol Ther 27:15. PUBMED Abstract
  40. Delatour P, Foot R, Foster AP, et al. 1996. Pharmacodynamics and chiral pharmacokinetics of carprofen in calves. Br Vet J 152:183. PUBMED Abstract
  41. EMEA. European Agency for the Evaluation of Medicinal Products (EMEA) Website: Committee for Veterinary Medicinal Products. 2011. Meloxicam. Maximum Residue Limit (MRL) Summary Report (2). [WWW page]. http://www.emea.europa.eu/pdfs/vet/mrls/057199en.pdf, accessed Mar 18, 2011.
  42. Stewart M, Stookey JM, Stafford KJ, et al. 2009. Effects of local anesthetic and nonsteroidal anti-inflammatory drug on pain responses of dairy calves to hot-iron dehorning. J Dairy Sci 92:1512. PUBMED Abstract
  43. Coetzee JF, Mosher RA, KuKanick B, et al. 2012. Pharmacokinetics and effect of intravenous meloxicam in weaned Holstein calves following scoop dehorning without local anesthesia. BMC Vet Res 8:153. PUBMED Abstract
  44. Coetzee JF, KuKanich B, Mosher R, et al. 2009. Pharmacokinetics of intravenous and oral meloxicam in ruminant calves. Vet Ther 10:E1. PUBMED Abstract
  45. Abrahamsen EJ. 2009. Chemical restraint in ruminants, pp 546-549. In Anderson DE, Rings DM (eds), Current veterinary therapy food animal practice, ed 5. Saunders Elsevier, St Louis, MO.
  46. Coetzee JF, Gehring R, Anderson DE, et al. 2010. Effect of sub-anaesthetic xylazine and ketamine (“ketamine stun”) administered to calves prior to castration. Vet Anaesth Analg 37:566. PUBMED Abstract
  47. Court MH, Dodman NH, Levine HD, et al. 1992. Pharmacokinetics and milk residues of butorphanol in dairy cows after single intravenous administration. J Vet Pharmacol Ther 15:28. PUBMED Abstract
  48. Baldridge SL, Coetzee JF, Dritz SS, et al. 2010. Pharmacokinetics and physiologic effects of xylazine-ketamine-butorphanol administered intramuscularly alone or in combination with orally administered sodium salicylate on biomarkers of pain in Holstein calves following concurrent castration and dehorning. Am J Vet Res 72:1305.
  49. Caron JP, LeBlanc PH. 1989. Caudal epidural analgesia in cattle using xylazine. Can J Vet Res 53:486. PUBMED Abstract
  50. Caulkett NA, MacDonald DG, Janzen ED, et al. 1993. Xylazine hydrochloride epidural analgesia—a method of providing sedation and analgesia to facilitate castration of mature bulls. Compend Contin Educ Pract Vet 15:1155.
  51. Grubb TL, Riebold TW, Crisman RO. 2002. Comparison of lidocaine, xylazine, and lidocaine–xylazine for caudal epidural analgesia in cattle. Vet Anaesth Analg 29:64.
  52. Postner LP, Burns P. 2009. Injectable anaesthetic agents, p 283. In Riviere JE, Papich MG (eds), Veterinary pharmacology and therapeutics, ed 9. Wiley-Blackwell, Ames, IA.
  53. Gehring R, Coetzee JF, Tarus-Sang J. 2009. Pharmacokinetics of ketamine and its metabolite norketamine administered at a sub-anesthetic dose together with xylazine to calves prior to castration. J Vet Pharmacol Ther 32:124. PUBMED Abstract
  54. Coetzee JF, Mosher RA, Kohake LE. 2011. Pharmacokinetics of oral gabapentin alone or co-administered with meloxicam in ruminant beef calves. Vet J 190:98. PUBMED Abstract

Further Reading

  1. Coetzee J. 2013. Pain management. Vet Clin North Am Food Anim Pract 29:1. PUBMED Abstract
  2. Kent JE, Molony V. Guidelines for the recognition & assessment of animal pain. University of Edinburgh, Edinburgh, UK. [WWW page]. http://www.vet.ed.ac.uk/animalpain/, accessed June 3, 2013.
  3. Manteca X, Millman ST. 2011. Special issue: pain in farm animals. Appl Anim Behav Sci 135:177.